When carrying out the design optimization of safety-related systems, it is crucial to enhance the economic efficiency of the unit while ensuring that the safety level meets regulatory standards. Therefore, nuclear safety impact analysis is an important task in the design optimization process. With the rapid development of pool-type sodium-cooled fast reactor technology in China and the accumulation of engineering experience by design units, to enhance the economic efficiency of nuclear power units, attempts have been made to optimize the architecture of the Distributed Control System (DCS) under the guidance of the “centralized display, distributed control” design principle. This has reduced the scale of the DCS and the amount of related cables, saving a significant amount on the procurement and installation costs of equipment and materials. Methods such as nuclear safety function analysis and seismic analysis are used to study the impact of DCS and related system optimization on the safety functions of the reactor, ensuring the safety of the reactor, personnel, and the environment. The research results can be applied to the construction of new pool-type sodium-cooled fast reactors, which is beneficial for reducing the overall cost of nuclear power units, and provides a reference for the organization and implementation of design optimization for similar reactor types, DCS architecture design, and related safety impact analysis.