Different from the current fire protection design assumptions of nuclear power plant, multiple fires may be occur simultaneously under earthquake condition, and in this case nuclear safety could faces severe challenges. With the frequency earthquake activities on the earth, it is imperative to investigate the conditions of fire caused by earthquake, establish suitable analytical processes and methodologies, formulate appropriate design assumptions, eliminate potential unsafe factors and ensure that nuclear safety functions remain unaffected by seismic-induce fires. This paper gives general introduction of assessment method of seismic-induced fire for HPR1000 Nuclear power plants, including basic assumptions, credited ignition sources screening criteria, numerical simulation analysis of fire, safe shutdown analysis, and protection measures which could be taken. The research and analysis methodology for seismic-induced fire presented in this paper is based on deterministic methods and could be applied for fire analysis for in-service, under-construction, and newly built nuclear power plants, identifying potential unsafe factors, implementing suitable fire protection measures, and enhancing the fire safety of HPR1000 nuclear power plants.