Inappropriate cockpit layout design may cause the rise of safety risk and decrease of work efficiency during flight. The improvement of cockpit ergonomics calls for efficient methods to assist the cockpit layout design and reduce the flight risk related to human factors as much as possible. This paper considers problem of cockpit layout optimization and specific research work are as follows: (1) Implement the partition ratings of accessibility and visibility area. Apply analytic hierarchy process (AHP) to combine accessibility and visibility into integrated ergonomics evaluation index. (2) Propose a layout search strategy based on particle swarm optimization (PSO) to improve the cabin layout design. Arrange the cockpit equipment of sorted importance by maximizing the integrated ergonomics evaluation index. (3) Finally, the method is employed in the case of angle of attack (AOA) indexer layout improvement, with the optimized layout checked by the ergonomics evaluation tool (DELMIA). As a result, the improvement of the integrated ergonomics evaluation index and ergonomics ratings demonstrates that this method performs well by providing better cockpit layout.