A universal configurable aircraft analog acquisition system is designed in this paper, which uses table-driven and channel switching technology to realize multi-modal working mode switching and multi-channel input switching. The root causes of errors is analyzed and calibration methods to address system errors are designed. For the system error, the effects of channel switching errors, A/D conversion errors, and system parameter offset errors were eliminated by zero level calibration, A/D conversion unit full amplitude calibration, and system full amplitude calibration. The three criteria and Dixon criteria were introduced for random and accidental errors, eliminating suspicious points of accidental errors and applying mean theory to eliminate the influence of random errors. Experimental results show that the simulation acquisition system and calibration method designed in this paper can realized high-precision and highly reliable acquisition of aircraft simulation systems, which has important practical significance for improving the control performance of aircraft electromechanical systems.