In recent years, the foldable structure derived from the origami style can serve as an acoustic waveguide and develop into an acoustic metamaterial. Based on ANSYS software, this paper studies the propagation of acoustic waves in the reconfigurable waveguide proposed by Babaee in 2016, and calculates the steady-state dynamic response of the system in a wide frequency ranges under three configurations. The response was compared with the simulation results and experimental data obtained by Babaee. The comparison shows that the calculation results of ANSYS are more consistent with the experimental results than Abaqus. It is completely feasible to calculate the frequency response of such reconfigurable origami acoustic metamaterials using ANSYS. For reconfigurable origami acoustic metamaterial variants, fluid-structure coupled harmonic response analysis must be implemented to account for interaction effects.