The HVAC system is an important auxiliary and support system in nuclear power plants. Some of its subsystems perform safety functions after design basis accidents, such as controlling the concentration of radioactive pollutants in the con-trolled area or ensuring the environmental conditions required for personnel habit-ability and equipment operation. Based on the requirements and characteristics of the HVAC system in the third-generation HPR1000, by summarizing the design experience of HVAC control systems in previous nuclear power plants and drawing on advanced control technologies in other fields, new control strategies have been proposed in the design of the nuclear power plant HVAC system, which has improved the automation and intelligence levels of the HVAC control system in nuclear power plants. The HVAC control system of the HPR1000 adopts control strategies such as one-key start-stop sequence control, intelligent variable air volume control, and energy consumption and energy-saving analysis, achieving a digital control application scheme that combines centralized management, monitoring, and decentralized layout. The HVAC control system of the nuclear power plant not only ensures the reliability and stability of the HVAC system operation but also improves the economy of the nuclear power plant. This control system has important reference value for the intelligent and digital solutions of other auxiliary and support systems, laying a solid foundation for the subsequent mass construction of HPR1000 units.