The Chinese HTR-PM project has attracted widespread attention because of its independent intellectual property rights, emphasizes safety, environmental protection, modularity, and application diversity. An important element in the NUREG-0711 review of the US Nuclear Regulatory Commission is task analysis, one of the important part is to evaluate the workload of nuclear power plant control room operators. However, there is still limited research on the workload of operators in the main control room of high-temperature gas-cooled reactors. Through comprehensive literature research, this paper reviews current methods for analyzing operator workload in the main control room of nuclear power plants, evaluating the strengths and weaknesses of each approach. Two prominent workload assessment methods—the Visual, Auditory, Cognitive, and Psychomotor (VACP) method, and the NASA Task Load Index (NASA-TLX)—have been selected for an in-depth evaluation in this study. The HTR-PM is employed as a representative case to explore these methods’ applicability, with a focus on operational scenarios involving the fuel loading and unloading system. To ensure robust and comprehensive workload analysis, a large-scale simulator of the high-temperature gas-cooled reactor control room environment is used, replicating realistic task conditions and operator interactions. Each method’s application is carefully calibrated to capture detailed workload variations during critical fuel handling operations, allowing for a systematic comparison and cross-validation of the methods. Results find that current operator workload in the main control room is slightly high, indicating a need for human factors improvements. It recommends integrating advanced automation and digital technologies to reduce workload, enhance the human–machine interface, and improve operational efficiency and decision-making, supporting the safe and efficient operation of high-temperature gas-cooled reactors.