Land degradation, often caused by natural and anthropogenic activities, poses a threat toward global food security, biodiversity, and overall ecosystem health. Plant beneficial rhizosphere microorganisms (PBRM), involving plant growth-promoting bacteria (PGPR) and mycorrhizal fungi, confront these issues through improvement of soil fertility, structure, and endurance. These microbes possess the abilities of nitrogen fixation, mineral solubilization, and produce plant growth hormones such as indole-3 acetic acid, gibberellins, and cytokinin. Additionally, PBRMs have a unique, diversified secondary metabolic profile that indirectly helps mitigate drought, salinity, and soil pollution, further improving soil water dynamics and its structure. Beyond this, PBRMs exhibit biocontrolling traits by releasing antibiotics, enzymes, and siderophores that suppress many pathogens and pests, thereby reducing the need for toxic chemicals in agriculture. Moreover, they aid in the bioremediation of soil pollution through heavy metal immobilization and detoxification, fostering a healthier and more sustainable ecosystem. Bioprospecting the role of plant beneficial rhizosphere microorganisms offers an economical and sustainable approach to degraded land restoration. Their incorporation into land management is not only limited to degraded land restoration, but they also support in achieving sustainable development goals related to food security, biodiversity conservation, and climate change mitigation.