Tomato leaf curl New Delhi virus (ToLCNDV), classified under the genus Begomovirus, is a positive-sense single-stranded DNA (ssDNA) virus primarily transmitted by the whitefly Bemisia tabaci. In recent years, ToLCNDV has emerged as a significant virus due to its broad host range and severe impact on a wide spectrum of economically important crops. The virus is associated with considerable yield losses, thereby posing a critical threat to global food security. Effective field management of ToLCNDV remains challenging, primarily due to the ubiquity of its vector, the presence of multiple whitefly biotypes, the persistent mode of transmission, and the limited availability of resistant cultivars. This chapter provides a comprehensive overview of ToLCNDV, focusing on its vector-mediated transmission dynamics, early detection strategies, and surveillance approaches using advanced diagnostic platforms, such as ELISA, loop-mediated isothermal amplification (LAMP), RT-LAMP, and CRISPR/Cas12a-based assays. Furthermore, the chapter explores integrated management frameworks combining conventional practices with innovative tools, including host plant resistance, RNA interference (RNAi), microRNAs (miRNAs), grafting techniques, and genome editing technologies, like CRISPR/Cas systems.