Corrosion in the mild steel (MS) is one of the important issues in several industries, and understanding its behavior in different environments is crucial for material to be durable. In this study, the corrosion rate of MS sample in different concentrations of HNO3 solution was studied using the weight loss (WL) method. To predict the corrosion rate at different temperatures, the response surface methodology (RSM) was employed, and optimization of corrosion rate was done using the same. The main aim was to increase material’s corrosion resistance and minimize the corrosion rate by finding the optimal conditions. Results showed that lowest corrosion rate was achieved at lowest concentration of HNO3 and room temperature. Also, to understand the corrosion mechanism, scanning electron microscopy (SEM) was used to study the corroded MS specimen surface.