NO is crucial for the homeostasis regulation of multiple systems in the body. Inorganic nitrates can regulate NO in vivo through the nitrate-nitrite-NO pathway, thereby playing an important physiological role in the maintenance of homeostasis. Sialin serves as a nitrate transporter, transporting inorganic nitrates into cells and organelles to facilitate different biological functions in cells. Thus, the inorganic nitrate-sialin system represents a fundamental mechanism underlying homeostasis regulation.