Aiming at the problems of cumbersome process, inefficient supplier management and cost overruns in the procurement of warehouse management services for nuclear power enterprises, this paper proposes an optimization strategy centered on centralized purchasing, strategic purchasing and e-procurement, and verifies its economic benefits with empirical analysis. It is found that the traditional procurement model leads to prolonged procurement cycle, increased quality risk and uncontrolled cost due to multi-level approval, insufficient information sharing and lack of supplier evaluation system. Through centralized purchasing to consolidate demand and standardize processes (e.g., CGN shortened the procurement cycle by 20% and reduced costs by 15%), strategic purchasing to introduce data analysis and dynamic supplier management (e.g., a warehousing project of CNPE realized accurate prediction of labor costs), and digital application of e-procurement platforms (e.g., CGN’s “e-buy” system The digital application of the e-procurement platform (e.g., the procurement efficiency of CGN’s “e-buy” system has increased by 30%) has significantly optimized the procurement efficiency and cost structure. Taking a storage project of CGN as an example, the optimized inventory turnover rate has increased by 10%-20%, saving tens of millions of yuan in annual operating costs, and the security of material management has been strengthened through hierarchical storage planning (e.g., thermostatic storage, chemical storage, etc.). It is proposed to apply centralized purchasing, strategic purchasing, e-procurement and other procurement strategies to optimize the procurement work, expecting to provide theoretical references for the optimization of the procurement mode of warehouse management services in nuclear power enterprises.