Neurogenesis and brain plasticity are essential processes underlying cognition and adaptability throughout life. In contrast to previous speculations, adult neurogenesis is ongoing, particularly in the hippocampus, a brain area of interest in learning and memory. Various factors like aging, stress, and neurodegenerative disease can perturb these processes. Nutraceuticals—biologically active food-derived molecules—have been identified as potential candidates to trigger synaptic plasticity and neurogenesis. Omega-3 fatty acids, flavonoids, curcumin, and phosphatidylserine are some molecules with neuroprotection by reducing oxidative stress, modulating inflammation, and promoting synaptic growth. These bioactive molecules account for cognitive health by modulating neurotransmitter systems, regulating neuronal survival, and inducing long-term potentiation. Lifestyle treatments like exercise, stress management, and nutritional balance also optimize neurogenesis and brain plasticity. While promising outcomes have been noted, optimal dosages, bioavailability, and long-term effectiveness of nutraceutical therapy need to be determined. Standardized guidelines must be drawn by further studies to ensure application to cognitive health practice. The use of nutraceuticals in inducing neurogenesis and brain plasticity and the evidence supporting that they are an organic and holistic remedy for the prevention of cognitive dysfunction and neurodegenerative disease are discussed in this chapter. With the combination of a healthy lifestyle and nutraceuticals, individuals can optimize brain function, enable memory retention, and achieve cognitive resilience throughout life. Specific molecular mechanisms and clinical applications need to be delineated in future studies to ensure the therapeutic action of these molecules in neurology.