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This case scenario discusses one of the rarest endocrine paraneoplastic syndromes in renal cell carcinoma, namely gynecomastia. An elderly male presented with rapidly progressive tender gynecomastia with weight loss was evaluated for an underlying etiology. He was found to have very high β-HCG and CEA. USG-guided FNAC of the kidney revealed metastatic renal cell carcinoma staining positive for β-HCG. He developed rapidly deteriorating neurologic deficit resulting from CNS metastatic deposit and succumbed to death shortly thereafter.

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A 60-Year-Old Male Presented with Bilateral Painful Gynecomastia

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  • 发表日期：

    2025年

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  • Sharmin Jahan

摘要

This case scenario discusses one of the rarest endocrine paraneoplastic syndromes in renal cell carcinoma, namely gynecomastia. An elderly male presented with rapidly progressive tender gynecomastia with weight loss was evaluated for an underlying etiology. He was found to have very high β-HCG and CEA. USG-guided FNAC of the kidney revealed metastatic renal cell carcinoma staining positive for β-HCG. He developed rapidly deteriorating neurologic deficit resulting from CNS metastatic deposit and succumbed to death shortly thereafter.