A common cause of dementia is Alzheimer’s disease (AD), which is a serious public health concern because of its rising prevalence around the globe. This degenerative neurological disease causes a steady decline in cognitive performance, behavior, and function. While the precise process of AD remains unclear, a number of variables, such as amyloid-beta (Aβ) deposition, tau protein alterations, neuroinflammation, oxidative stress, and transition metal imbalance, are believed to play a role in the disease’s development. The goals of AD treatment are to reduce symptoms, slow the development of the illness, and enhance patients’ quality of life. Treatment approaches include pharmacological therapies, various nanoparticle formulations, stem cell therapies, and lifestyle modifications. The study investigates the potential of nuts in managing and preventing AD. Nuts are foods high in nutrients that have antioxidant and anti-inflammatory properties. They are rich in bioactive ingredients, including phenolic compounds, fiber, vitamins, minerals, phytosterols, and unsaturated fatty acids. These components are known to have positive effects on brain function through their neurotrophic, antioxidant, and anti-inflammatory properties. Nuts are thought to exert neuroprotective effects through various mechanisms such as reducing oxidative stress, reducing inflammation, increasing synaptic plasticity, and reducing amyloid beta deposition. This study examines in detail the nutritional contents, phytochemical constituents, and potential effects on AD of various nuts such as almonds (Prunus dulcis Mill. DA Webb), Brazil nuts (Bertholletia excelsa Humb. & Bonpl), chestnuts (Castanea sativa Mill.), pine nuts, (Pinus pinea L.), hazelnuts (Corylus avellana L.), walnuts (Juglans regia Linn.), and Pistachios (Pistacia vera L.). It is emphasized that each of these nuts may target different aspects of AD through their specific constituents and play a valuable role in the prevention and management of the disease.

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The Role of Nuts in Alzheimer’s Prevention and Management

  • Gamze GÖGER,
  • Nagehan SALTAN

摘要

A common cause of dementia is Alzheimer’s disease (AD), which is a serious public health concern because of its rising prevalence around the globe. This degenerative neurological disease causes a steady decline in cognitive performance, behavior, and function. While the precise process of AD remains unclear, a number of variables, such as amyloid-beta (Aβ) deposition, tau protein alterations, neuroinflammation, oxidative stress, and transition metal imbalance, are believed to play a role in the disease’s development. The goals of AD treatment are to reduce symptoms, slow the development of the illness, and enhance patients’ quality of life. Treatment approaches include pharmacological therapies, various nanoparticle formulations, stem cell therapies, and lifestyle modifications. The study investigates the potential of nuts in managing and preventing AD. Nuts are foods high in nutrients that have antioxidant and anti-inflammatory properties. They are rich in bioactive ingredients, including phenolic compounds, fiber, vitamins, minerals, phytosterols, and unsaturated fatty acids. These components are known to have positive effects on brain function through their neurotrophic, antioxidant, and anti-inflammatory properties. Nuts are thought to exert neuroprotective effects through various mechanisms such as reducing oxidative stress, reducing inflammation, increasing synaptic plasticity, and reducing amyloid beta deposition. This study examines in detail the nutritional contents, phytochemical constituents, and potential effects on AD of various nuts such as almonds (Prunus dulcis Mill. DA Webb), Brazil nuts (Bertholletia excelsa Humb. & Bonpl), chestnuts (Castanea sativa Mill.), pine nuts, (Pinus pinea L.), hazelnuts (Corylus avellana L.), walnuts (Juglans regia Linn.), and Pistachios (Pistacia vera L.). It is emphasized that each of these nuts may target different aspects of AD through their specific constituents and play a valuable role in the prevention and management of the disease.