This chapter highlights the critical role of neuroinflammation in the onset and progression of Alzheimer’s disease (AD). Despite decades of research and the development of pharmacological treatments since the 1980s, a definitive cure for AD remains elusive. Current pharmacotherapies primarily aim to alleviate symptoms rather than halt or reverse the disease process. Consequently, strategies focused on prevention and delaying disease onset have become increasingly important. Among these strategies, anti-inflammatory dietary intervention holds significant promise due to its accessibility and daily relevance. Emerging research emphasizes the influence of the gut–brain axis, as well as antioxidant and anti-inflammatory pathways in linking diet to neuroinflammation and cognitive health. This chapter explores how the rich source of anti-inflammatory and antioxidant components in diets may serve as an adjunctive approach in modifying AD. The dietary modification interventions can be achieved by (1) increasing intake of anti-inflammatory dietary components via polyphenol-rich foods, omega-3 fatty acids, and essential vitamins; (2) adopting anti-inflammatory diets such as the Mediterranean or ketogenic diets; (3) modulating the gut microbiota through probiotics, prebiotics, and dietary fibre; (4) reducing processed foods and excessive sugar intake to minimize systemic inflammation. The take home message is that incorporating anti-inflammatory foods into the daily diet offers an accessible and practical strategy to reduce neuroinflammation, support cognitive function, and potentially prevent or delay the onset of Alzheimer’s disease.