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Amyloid-beta (Aβ) plaques, tau neurofibrillary tangles, oxidative stress, and neuroinflammation are the hallmarks of Alzheimer’s disease (AD), a progressive neurodegenerative illness. Emerging evidence suggests that dietary components can play a protective role in AD by targeting key pathological mechanisms. This chapter explores the molecular basis of the neuroprotective effects of various dietary bioactives, including polyphenols, omega-3 fatty acids, vitamins, minerals, trace elements, and other phytochemicals. These compounds exert beneficial effects through multiple pathways, such as reducing Aβ aggregation, modulating tau phosphorylation, mitigating oxidative stress, and suppressing neuroinflammation. Additionally, dietary components influence gut microbiota composition and epigenetic modifications, further contributing to cognitive resilience. Understanding the molecular interactions between diet and AD pathology may pave the way for novel dietary interventions and therapeutic strategies. This chapter provides a comprehensive overview of current findings and highlights future directions for research on nutrition-based neuroprotection against AD.

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Molecular Basis for the Protective Effect of Dietary Components Against Alzheimer’s Disease

  • 章节

  • 发表日期：

    2026年

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  • Kajal Bagri,
  • Shilpa Kumari,
  • Mahendra Bishnoi,
  • Rahul Deshmukh

摘要

Amyloid-beta (Aβ) plaques, tau neurofibrillary tangles, oxidative stress, and neuroinflammation are the hallmarks of Alzheimer’s disease (AD), a progressive neurodegenerative illness. Emerging evidence suggests that dietary components can play a protective role in AD by targeting key pathological mechanisms. This chapter explores the molecular basis of the neuroprotective effects of various dietary bioactives, including polyphenols, omega-3 fatty acids, vitamins, minerals, trace elements, and other phytochemicals. These compounds exert beneficial effects through multiple pathways, such as reducing Aβ aggregation, modulating tau phosphorylation, mitigating oxidative stress, and suppressing neuroinflammation. Additionally, dietary components influence gut microbiota composition and epigenetic modifications, further contributing to cognitive resilience. Understanding the molecular interactions between diet and AD pathology may pave the way for novel dietary interventions and therapeutic strategies. This chapter provides a comprehensive overview of current findings and highlights future directions for research on nutrition-based neuroprotection against AD.