The water chemistry environment of the primary circuit directly affects the integrity of fuel cladding. Specifically, an increase in Li concentration and pH value will have a significant negative impact on the corrosion behavior of zirconium alloys. Autoclave corrosion tests with different water chemistry (4.5 ppm/7.2, 4.5 ppm/7.5, 7 ppm/7) are carried out to study the effects of oxide film thickness and hydrogen absorption for zirconium alloy corrosion. The experiments show that the oxide film thickness and hydrogen content of each zirconium alloy increased. The thickness of CZ1 and CZ2 cladding oxide film was lower than that of Zr1-Nb and Zr-4 cladding, and the zirconium alloy has no obvious corrosion, indicating that the CZ alloy has good water chemistry adaptability.