i-UDS is an indispensable investigation in the management of patients with neurogenic bladder (NB). Although the basic endpoints of management—keeping the upper tracts safe and allowing the child to be socially continent—remain the same for all the patients, the behaviour of each individual neurogenic bladder is distinctive and requires an individualised plan of care. i-UDS provides immense information about the functioning of these bladders, and i-UDS-based management of filling phase pressures leads to the recovery of the bladder and prevents upper tract damage in several cases. Urinary incontinence is a common phenomenon in these children, but the cause of leak is diverse. It is important to understand the cause of incontinence in an individual child to be able to make him/her dry. Few children with NB have the ability to void on their own, but the mechanism of voiding varies. This chapter elucidates the different causes of urinary incontinence and voiding patterns in such children with NB, the relevance of this knowledge and the management of such patients. At the end, a few case scenarios have been depicted to illustrate the usefulness of serial UDS and highlight the improvement in bladder dynamics as well as symptoms.