The removal of hydrogen sulphide (H2S) from industrial gas streams is a critical requirement in petrochemical, biogas, and wastewater treatment applications. Conventional adsorbents, such as activated carbon, suffer from reduced performance under humid conditions and limited regeneration potential. In this study, we present a market-oriented evaluation of shaped MIL-101(Cr) metal–organic framework (MOF) extrudates as a promising alternative for H2S capture under conditions relevant to industrial applications. The material was synthesised via a hydrofluoric acid (HF)-free route using nitric acid (HNO3) as a safer and more scalable alternative. It was subsequently shaped into mechanically stable extrudates using methyl cellulose as a binder. Adsorption experiments were carried out using a dynamic breakthrough setup at 70% relative humidity to simulate realistic operating conditions. A breakthrough time of 1 min was observed for the adsorption process. During the desorption process at 200 °C, a maximum desorption concentration of 39 ppm was recorded after 110 min, and complete desorption was achieved in 165 min. The integration of HF-free synthesis, shape engineering, and high-humidity testing represents a crucial step toward the industrial deployment of MOF-based adsorbents. This work highlights the potential of MIL-101(Cr) extrudates as a next-generation sorbent for sustainable H2S removal in humid gas purification systems.