This chapter explores positional therapy as an effective management strategy for sleep-disordered breathing, particularly in cases with positional obstructive sleep apnea. It discusses the mechanisms, types, and clinical implications of positional therapy, including the use of vibratory devices and integration with continuous positive airway pressure therapy. The chapter also reviews diagnostic techniques, surgical interventions, and nasopharyngoscopy’s role in evaluating airway status. Future directions emphasize enhancing patient-centered outcomes, with research needed on long-term adherence, cost-effectiveness, and impacts on broader health conditions such as cardiovascular disease, metabolic syndrome, and neurocognitive disorder.