The phenotypic and genotypic plasticity of Candida species has been extensively characterized in Western literature, while countries in the Eastern Hemisphere are increasingly incorporating these findings into both research and clinical strategies. In Southeast Asia, however, the landscape is more complex. Some nations have taken a more limited role, focusing primarily on clinical identification, with research and surveillance receiving less emphasis. Conversely, other countries in the region actively contribute to global efforts to monitor Candida, including the surveillance of multidrug-resistant strains such as Candidozyma auris. The historical context, distribution patterns, and regional insights into Candida across Southeast Asian countries have been explored in various individual publications; however, a more comprehensive and comparative analysis remains limited. This chapter addresses the gap by presenting an up-to-date, region-wide synthesis of Candida-related data throughout Southeast Asia.