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Endemic mycoses, including cryptococcosis, aspergillosis, mucormycosis, talaromycosis, histoplasmosis, sporotrichosis, Pneumocystis jirovecii, and tinea capitis, present significant health challenges in Southeast Asia. We summarize the available evidence of the burden of these diseases in Southeast Asia, as well as the current available diagnostic tests, and their associated disease manifestations. Recent advancements in understanding the pathogenesis underlying these infections are summarized in this chapter as well in terms of innate and adaptive immunity. Current state-of-the-art vaccine development efforts for each of these mycoses exploring innovative approaches to induce effective immune responses in a safe manner are also presented in detail.

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Endemic Mycoses of Southeast Asia: Epidemiology, Diagnostics, Immunologic Insights and Vaccine Development

  • 章节

  • 发表日期：

    2026年

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  • Kin Israel R. Notarte,
  • Connie Cañete-Gibas,
  • Timothy Hudson David Culasino Carandang,
  • Adriel Pastrana,
  • Gerald Manalo,
  • Jeremy Ace Ng,
  • Po-Ying Chia

摘要

Endemic mycoses, including cryptococcosis, aspergillosis, mucormycosis, talaromycosis, histoplasmosis, sporotrichosis, Pneumocystis jirovecii, and tinea capitis, present significant health challenges in Southeast Asia. We summarize the available evidence of the burden of these diseases in Southeast Asia, as well as the current available diagnostic tests, and their associated disease manifestations. Recent advancements in understanding the pathogenesis underlying these infections are summarized in this chapter as well in terms of innate and adaptive immunity. Current state-of-the-art vaccine development efforts for each of these mycoses exploring innovative approaches to induce effective immune responses in a safe manner are also presented in detail.