The aim of this work is to search the capability of the three primary fuel types of PWR—UO2, (Th,U)O2, and MOX—to effectively use TRU and transmute minor actinide (MA) resulting from the nuclear waste while maintaining key operational parameters at an acceptable level. In this study, based on the Chinese HPR1000 reactor, and the Monte Carlo Code is employed to analyze the impact of incorporating 0.5 wt% TRU into these fuels on the finite multiplication factor (keff), effective fraction of delayed neutrons (βeff), neutron flux (Φ), fuel temperature coefficient (αT), void reactivity coefficient (αV), and actinide concentration. The potential of TRU to control the reactor’s residual reactivity is also explored. By examining the transmutation of MA with burnup, the study seeks to identify the fuel type most capable of consuming quantities of MA. The transmutation of MA in pressurized water reactors (PWRs) influences the radioactivity levels of spent fuel, and the primary operational parameters are evaluated to assess the feasibility of TRU utilization in PWRs. The performance of the three nuclear fuels with added TRU nuclides is comprehensively evaluated by TOPSIS analysis method, a recognized multi-criteria decision-making approach, to identify the optimal fuel type. The evaluation results indicate that the feasibility of nuclear fuel (Th, U) O2 used to utilize TRU and transmute MA elecs the most feasible in terms of neutron physics. The results of this study can provide new ideas and theoretical guidance for the design of new nuclear fuel for TRU utilization and MA transmutation in PWR.