The structural and technological advancements in the aquaculture industry may impact access and intellectual property rights (IPR) regimes. These topics will be covered broadly, including their partially inherent contradictions that must be resolved for sustainable development and their immediate and long-term biological effects, ethical considerations, and other social aspects (economic, legal, and political issues). Genomic research (GR) is becoming a potential technique in aquaculture for fish and shellfish breeding and for creating substitute feed sources and disease-fighting vaccinations. However, using GR in aquaculture has ethical, economic, and ecological issues. It is essential that suitable scientific research and ethical considerations be carried out before the widespread adoption of GR products, such as DNA/Genetic Engineering (GE) vaccines and GM feed in commercial fish farming, to achieve a sustainable introduction of GR. This could provide a strong foundation for preventing possible harmful environmental and human health impacts. Positive markets and customer reactions are possible if GE can contribute to the development of aquaculture as a sustainable business. Involving stakeholders from the conceptual to the commercial stages and promoting a transparent approach that aims to identify decisive-stakeholders, informed research, which can impact the creation, adoption, and application of proactive policies.