This paper investigates the aerodynamic effects of load deformation on the forward fuselage of civil aircraft. The study begins by analyzing the typical structural characteristics and load deformation distribution of the forward fuselage. Based on the finite element analysis results, the deformed shape of the forward fuselage under typical cruise conditions is simulated. The aerodynamic influence of local deformation is evaluated by using computational fluid dynamics (CFD) methods. The results show that the aerodynamic performance, including drag coefficient and pressure distribution, is sensitive to local shape changes, especially in the boarding gate area. Finally, two control strategies, passive control, and active control, are proposed to minimize the adverse aerodynamic effects caused by load deformation of the forward fuselage.