Currently, after the batch production and use of the centrifugal pump, there is an obvious phenomenon of vibration dispersion. Aiming at the convergence of vibration and noise control of batch centrifugal pump products, this paper carries out the research from the point of view of process. From the perspective of location and optimization of the key process parameters affecting vibration and noise, focusing on the main excitation sources of centrifugal pumps. Taking the clearance between the wear ring and the impeller as the research object, comprehensive consideration of the influence of error of wear ring clearance on flow-induced vibration of pump, utilizing three-dimensional dimensional chain modeling and analysis to screen out the key process parameters that affect vibration. Based on mathematical statistics, fluid numerical simulation and fluid–structure interaction, the impact of key process parameters on error of the wear-ring clearance, which the dispersion level of vibration is obtained. Finally, an experimental control group is established to verify the key process parameters.