Aiming at the effectiveness evaluation requirements of the space information system, this paper analyzes the difficulties in the modeling and effectiveness evaluation of the space system. A composable and reusable model framework for the space information system and an agent behavior modeling method oriented towards multi-domain connectivity, information processing, and resource management and control are established. A modeling, simulation, and effectiveness evaluation method based on ABMS (Agent Based Modeling and Simulation) for the space cyber information system is proposed. Eventually, the effectiveness of this technology is verified through typical application cases, thereby providing a quantitative analysis tool for system design and evaluation in relevant fields.