To investigate the influence of different tube on slender body during large-slip axial motion, a coupled finite element model was established and coupled with the VUAMP subroutine. The process of large-slip axial motion of the slender body was then simulated using Abaqus software. The motion states and surface morphologies of slender bodies moving in three tubes, namely an 820 mm rectangular tube, an 850 mm rectangular tube and an 820 mm polygonal tube were compared. The simulation results demonstrate that the slender body of the polygonal tube exhibits faster in-tube motion, little motion disturbance, and more stable motion. Additionally, its horizontal direction centroid offset is only 5% of that of the rectangular tube. Furthermore, the slender body of the polygonal tube exhibits minimal stress-strain characteristics. The surface morphology of the slender body of the polygonal tube is not conspicuous at the valleys and hills boundaries and the scratch grooves of the slender body of the rectangular tube are deep. The above obvious different surface morphologies should result in great influence on aerodynamic parameters.