The excellent mechanical and biological properties of magnesium-based biomaterials (MBMs) make them among the most intriguing options for bioengineering. This chapter includes the clinical trials, benefits, and difficulties of MBMs for bio applications—particularly tissue regeneration and repair. The use of MBMs started in the early 1900s, and the revolutionary developments in their current uses in fields like cardiology and orthopaedic surgery are highlighted. This study also indicates that to enhance complex tissue repair, future studies will concentrate on surface modification, alloy composition optimisation, and the investigation of cutting-edge technologies like 3D printing. MBMs have a great deal of promise for tissue engineering and regenerative medicine, which calls for more research and interdisciplinary cooperation to optimise their therapeutic benefits.