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This study investigated the impact of Gac Aril Carotenoid-Rich Extract (GACRE) on the expression of key adipogenic genes—PPARγ, C/EBP, and UCP1—in white and brown adipose tissues (WAT and BAT) of rats fed a high-fat diet. The experiment used real-time PCR to quantify gene expression, normalized to GAPDH. In WAT, PPARγ expression was downregulated in normal diet controls compared to high-fat diet groups, while C/EBP and UCP1 levels were elevated in GACRE-treated rats. Notably, rats receiving 200 mg/kg GACRE showed higher UCP1 expression. In BAT, PPARγ was downregulated in control rats, while C/EBP was elevated with GACRE treatment. UCP1 expression was lower in high-fat diet groups but increased with 200 mg/kg GACRE. Comparing WAT and BAT, PPARγ and UCP1 were higher in BAT, with GACRE reducing the expression gap between the tissues. The findings suggest that GACRE supplementation may modulate gene expression related to adipogenesis and thermogenesis, indicating its potential in managing obesity and metabolic disorders. Further research is warranted to explore these benefits.

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Modulation of PPARγ, C/EBP, and UCP1 Gene Expression by Gac Aril Carotenoid-Rich Extract in High-Fat Diet-Fed Sprague Dawley Rats

  • 会议论文

  • 发表日期：

    2026年

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  • Mohd Nazri Abdul Rahman,
  • Amin Ismail,
  • Azrina Azlan,
  • Ahmad Fazli Abdul Aziz,
  • Nor Hayati Muhammad,
  • Ruzaidi Azli Mohd Mokhtar,
  • Ali Abdulqader

摘要

This study investigated the impact of Gac Aril Carotenoid-Rich Extract (GACRE) on the expression of key adipogenic genes—PPARγ, C/EBP, and UCP1—in white and brown adipose tissues (WAT and BAT) of rats fed a high-fat diet. The experiment used real-time PCR to quantify gene expression, normalized to GAPDH. In WAT, PPARγ expression was downregulated in normal diet controls compared to high-fat diet groups, while C/EBP and UCP1 levels were elevated in GACRE-treated rats. Notably, rats receiving 200 mg/kg GACRE showed higher UCP1 expression. In BAT, PPARγ was downregulated in control rats, while C/EBP was elevated with GACRE treatment. UCP1 expression was lower in high-fat diet groups but increased with 200 mg/kg GACRE. Comparing WAT and BAT, PPARγ and UCP1 were higher in BAT, with GACRE reducing the expression gap between the tissues. The findings suggest that GACRE supplementation may modulate gene expression related to adipogenesis and thermogenesis, indicating its potential in managing obesity and metabolic disorders. Further research is warranted to explore these benefits.