Interconnected supply chains and enhanced efficiency, transparency, and security have become paramount in the modern business world. In response to this demand, blockchain technology has emerged as a disruptive influence positioned to fundamentally reshape supply chain management. This chapter delves into the transformative potential of blockchain in supply chain management, exploring its multifaceted applications and profound impact on various supply chain stages. It also highlights modern supply chains’ complexities and challenges, emphasizing the need for innovative solutions. Subsequently, blockchain enhances transparency and traceability, enabling seamless tracking of products throughout the supply chain. Blockchain optimizes inventory management, streamlining procurement and reducing costs. The chapter also outlines how blockchain streamlines logistics and transportation, simplifies customs clearance, and reduces delays. Additionally, it explores how blockchain empowers sustainable practices within supply chains, enabling transparent tracking of environmental impact data. It also delves into how blockchain fosters collaborative innovation, providing a secure platform for sharing data and insights among supply chain partners. Real-world examples from various industries, including gems, food, and pharmaceuticals, demonstrate the practical applications of blockchain in supply chain management. The chapter discusses blockchain's transformative potential in revolutionizing supply chain management. It emphasizes the transformative impact of blockchain in improving transparency, streamlining logistics, empowering sustainable practices, fostering collaborative innovation, and increasing adoption of blockchain technology, as well as its significant potential to revolutionize supply chains, rendering them more interconnected, streamlined, and reliable networks.