This chapter elucidates the empirical endeavour to investigate the relationship between psychological distress, body image dissatisfaction, and mental health in working and non-working women in the course of pregnancy, in addition to the moderating role of social support. This chapter covered the cross-sectional study and was conducted on a purposive sample of 213 pregnant women. Findings revealed that women's negative observations about their body image also dissatisfaction with their body are positively correlated to psychological distress but negatively correlated to mental well-being and non-significant correlation with social support. Psychological distress is negatively correlated to mental well-being and social support, and its constructs are negatively allied to mental distress. The outcomes of the Hierarchical Regression analysis showed that body image dissatisfaction significantly negatively, social support positively, and psychological distress did not significantly predict mental well-being. Marriage duration of 16 years or above was positively predicted, and the age range of 31 to 40 years was significantly strongly and positively predicted, but higher secondary education negatively predicted mental well-being. Moreover, high-level social support was revealed to be a significant moderator in the association of dissatisfaction with body image as well as mental well-being. Results revealed that working women suffered from mental health problems and perceived more social support compared to non-working females. This chapter may help families, especially spouses to understand their partner's well-being-related problems during pregnancy, as well as the importance of social support. It also helps human resource management to facilitate pregnant females by establishing a comfortable environment to get maximum output from them at work.