Gene-based therapies are a novel approach to treating a wide range of diseases that are now incurable. However, gene therapies biological applications have been severely limited by their delicate nature. Thus, for gene-based treatments, the development of gene-delivery vectors is key. Gene deliveryGene delivery has been accomplished through the development and application of numerous gene-delivery vectors. They can generally be divided into vectors that are viral and those that are not. Non-viral vectors have emerged in recent years, garnering a lot of attention from researchers due to safety concerns with viral vectors. Among these polymeric, non-viral vectors have been favored because of their low immunogenicity, simplicity in manufacturing, regulated chemical makeup, and great chemical adaptability, making them the perfect substitute for viral vectors. With their favorable biocompatibilityBiocompatibility and biosafety, biodegradable polymers, in particular, have been seen as having a lot of promise for use in therapeutic settings. The purpose of this review is to provide the latest advancements in biodegradable polymers for gene deliveryGene delivery applications, with a focus on their capability for gene transfer, chemical structure design, and other biological functions. Accordingly, we identify and classify biodegradable polymers first, then go on to explain the mechanismsMechanism of breakdown associated with each. We will introduce and analyze the various biodegradable polymer types that arise from natural and manmade polymers, as well as their potential uses in gene transfer. Lastly, an outlook for the future of biodegradable polymer vector development will be provided.