Sustainability is a much-needed approach in the present scenario. The rising population leads to an exhaustive demand for resources and infrastructure. Therefore, integrating circular design principles with biomanufacturing processes provides a transformative approach to sustainable production within the circular bioeconomy framework. The technological advancements in biomanufacturing, such as fermentation, metabolic engineering, synthetic biology, and waste valorisation, enable the conversion of waste biomasses into valuable products of regular and commercial use. The other physicochemical approaches, including hydrothermal liquefaction (HTL), gasification, and anaerobic digestion, add dynamic synergy in this conversion process. This chapter delves into the integration of various strategies, such as design for disassembly (DfD), upcycling, and sustainable material selection, along with life cycle assessment (LCA), that can minimise the environmental impact in the life cycles of the product. The closed-loop production models encourage efficiency and sustainability by using waste products from one process as inputs for another. The case studies mentioned in the chapter highlight the practical applications and advantages of integrating circular design with biomanufacturing. The chapter also explores the technological and economic limitations, along with policy hurdles. To overcome these obstacles, cooperation, legislative backing, and ongoing innovation are needed. The chapter ends by highlighting how this integrated approach can promote a resilient bioeconomy and sustainable industrial practices.