On the journey of educational modernization, information technology is reshaping the educational landscape, empowering the “Educating Five Domains Simultaneously” comprehensively and deeply, becoming the key driver for digital transformation in education. This article analyses 87 typical national cases in depth, systematically elaborating innovative practices and transformation paths of information technology in “Educating Five Domains Simultaneously”. It aims to offer references and inspirations for educators, researchers, and those concerned with education. Together, we explore future directions for information technology in high-quality educational development, aiding comprehensive elevation of educational goals in the digital era and cultivating well-rounded talents suited to the times.