The healthcare sector is rapidly applying artificial intelligence (AI), including Generative AI, to realize new products and services. The integration across the logistics chains and value stack has created new service opportunities from the frontline general practice, outpatient care, hospitals, homecare, preventative care, patient support, logistics, pharmacy, research, ancillary services, waste disposal, or government oversight and reporting. The impact of the uptake of AI needs to address the pragmatics and practicalities of business areas like governance, legal, financial, regulatory, compliance, assurance, audit, people, stakeholders (agencies, vendors, partners), as well as services and operations and other prerequisites (project management, change management, readiness, testing). Healthcare-related businesses and areas are incorporating AI and responding to AI and data needs. Areas like risk management and business continuity also have a need to incorporate and optimize their functions. This chapter explores the application of AI to optimize operations and services, resulting in an efficient and effective healthcare enterprise.