Dementia is increasing worldwide and is likely to continue. With no long-term interventions and high associated costs, prevention by addressing risk is important. To inform prevention strategies, analyses in a recent UK cohort were conducted to understand current risk factor trends associated with global cognition, memory recall, and subjective memory to reflect dementia risk. Data from UK older adults (≥65 years) (N = 541) of the Cognitive Function and Ageing Study IICognitive Function and Ageing Study-II were analyzed. Risk variables included sociodemographics, health, functional ability, physical activity, and walking. Novel risk factors, such as technology access and confidence and hearing loss, were also included. Cross-sectional relationships with cognition and subjective memory were analyzed using regression models. For Mini-Mental State Examination (MMSE)Mini-Mental State Examination (MMSE), variables accounted for 22% variance. Frequent walking, a mid-high socioeconomic status, and technology confidence predicted better MMSE performance, whereas being single predicted poorer. Immediate recall variables accounted for 12% variance, with moderate-intensity exercise and technology confidence predicting better recall. Poor recall was associated with being single, a low socioeconomic position, and hearing aid use. For delayed recall (13%), technology confidence and being a woman predicted better recall, whereas being single, low socioeconomic status, and older age predicted poor scores. For subjective memory (9%), excellent self-reported health and technology confidence predicted higher-rated memory, whereas hearing aid use predicted lower ratings. This study identified and substantiated modifiable, non-modifiable, and sociodemographic factors associated with global cognition, memory, and subjective memory. Future research should consider the interactions between these factors when improving the evidence base to strengthen knowledge of prevention strategies.

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Determining the Predictors of Dementia Risk in UK Older Adults: Results from the Cognitive Function and Ageing Study II

  • Manisha Jain,
  • Ahmet Begde,
  • Carol Brayne,
  • David Maidment,
  • Rachael Brooks,
  • Tom Dening,
  • Linda Barnes,
  • Eef Hogervorst

摘要

Dementia is increasing worldwide and is likely to continue. With no long-term interventions and high associated costs, prevention by addressing risk is important. To inform prevention strategies, analyses in a recent UK cohort were conducted to understand current risk factor trends associated with global cognition, memory recall, and subjective memory to reflect dementia risk. Data from UK older adults (≥65 years) (N = 541) of the Cognitive Function and Ageing Study IICognitive Function and Ageing Study-II were analyzed. Risk variables included sociodemographics, health, functional ability, physical activity, and walking. Novel risk factors, such as technology access and confidence and hearing loss, were also included. Cross-sectional relationships with cognition and subjective memory were analyzed using regression models. For Mini-Mental State Examination (MMSE)Mini-Mental State Examination (MMSE), variables accounted for 22% variance. Frequent walking, a mid-high socioeconomic status, and technology confidence predicted better MMSE performance, whereas being single predicted poorer. Immediate recall variables accounted for 12% variance, with moderate-intensity exercise and technology confidence predicting better recall. Poor recall was associated with being single, a low socioeconomic position, and hearing aid use. For delayed recall (13%), technology confidence and being a woman predicted better recall, whereas being single, low socioeconomic status, and older age predicted poor scores. For subjective memory (9%), excellent self-reported health and technology confidence predicted higher-rated memory, whereas hearing aid use predicted lower ratings. This study identified and substantiated modifiable, non-modifiable, and sociodemographic factors associated with global cognition, memory, and subjective memory. Future research should consider the interactions between these factors when improving the evidence base to strengthen knowledge of prevention strategies.