This chapter examines the impact of emerging technologies on design innovation and intellectual property protection, with particular emphasis on the applications and challenges posed by artificial intelligence, 3D print, and the IoT in the design field. The analysis begins with an in-depth exploration of how AI assists product design by simulating human cognitive processes, including stimulating creativity, identifying user preferences, generating design variants, and enabling non-professionals to participate in the design process. Subsequently, the discussion elaborates on the fundamental principles and advantages of 3D print design, supported by practical application cases across various domains such as smart healthcare and architecture. The examination further extends to the significance of IoT design and its potential for enhancing efficiency while reducing operational costs. Regarding design innovation based on social issues, the chapter highlights digital solutions for epidemic response, improvements in smart healthcare services, and ecological protection initiatives. The smart healthcare section specifically details the intelligent transformation spanning disease prevention, health management, and clinical treatment support systems, while emphasizing the critical role of data-driven methodologies. The final section addresses the challenges that design innovation presents to existing intellectual property frameworks, particularly concerning copyright attribution for AI-generated content and the legal characterization of NFT. The analysis advocates for establishing a reformed IP system to accommodate digital economic development, proposing measures such as strengthening IP regimes, supporting judicial practice, and developing effective dispute resolution mechanisms.