Shear walls are reinforced concrete walls that extend from the basement throughout the entire height of the building to resist lateral forces. The main objective of the present study is to study the performance of the different frame models with different positions of shear walls and openings with an inclined column by pushover analysis using ETABS 18.0. The significance of this study lies in evaluating the combined influence of staggered shear wall openings and inclined column configurations on seismic response reduction factors. Shear walls are placed around the core and along the periphery, with their peripheral positions modified to analyze storey displacement and drift. The adequate position of the shear wall in this study was determined by modelling four different configurations for the 56, 72, and 88 m heights of the building. The models are incorporated with 5, 10, and 15% of openings in both regular vertical and staggered shear wall openings with square and rectangular shapes. The performance of the staggered shear wall openings is superior to that of the vertical shear wall openings. Column inclinations of 15°, 30°, and 45° are provided with varying percentages, sizes, and shapes of openings along with the staggered shear wall. The results show that buildings with a 30° column inclination exhibit less lateral displacement and perform better compared to those with 15° and 45° inclinations. Also, response reduction factors, indicative of seismic response, are determined for staggered shear walls with inclined columns and the values are compared. The response reduction factor increases with building height for shear walls containing 5, 10 and 15% of openings.