Two-dimensional (2D) materials are currently in limelight for water splitting applications by virtue of their exceptional physicochemical and electrochemical properties. Despite their excellent performance, interlayers restacking due to inherent Van der Waal forces which retards ionic conductivity and making them imperative for electrochemical performance in practical applications. Among various approaches, integration of 2D materials found to be promising in water splitting processes as it finely tunes the electronic band structure by synergically providing maximum surfacial active sites; facilitating swift charge transfer kinetics; high thermodynamic stability and catalytic activity as compared to their single counterparts. Accordingly, this book chapter will focus on the recent developments advanced fabrication techniques, functionalization of 2D materials by integrating them with materials of different dimensions to enhance their catalytic activity for water-splitting applications. Additionally, comprehensive understanding and in-depth analysis of electrochemical processes involved in oxygen evolution reaction (OER), hydrogen evolution reaction (HER) and photoelectrochemical (PEC) water splitting processes have been acknowledged. Finally, the chapter addresses current key challenges and proposes future directions for developing high-performing 2D material based electrocatalysts for efficient hydrogen production as a key to next-generation energy solutions.