The regional settlement of migrants and humanitarian entrants play a vital role in enabling new arrivals and those undertaking secondary migration journeys, to rebuild their lives across Australia’s vast landscape. Regional settlement of migrants provides valuable injection of human capital and financial resources to the regional communities. Understanding placed-based responses and enabling factors that facilitate meaningful interactions between new and existing communities is essential to shaping effective policies and practices. While many factors contribute to the success of regional settlement models, I argue that success requires an intersectional approach informed by gender analysis. Highlighted in recently published report by Australia’s National Research Organisation for Women’s Safety Limited (Segrave 2023) titled “Migrant and refugee women: A national study of experiences of, understandings of and responses to sexual harassment in the workplace”, argue that siloed responses are ineffective. Regional settlement planning cannot succeed without a gender lens and integrated approaches that ensure women from diverse migrant and refugee backgrounds can thrive safely and equally within regional communities. The intersection of various forms of harm—such as exploitative work conditions, sexual harassment, racial discrimination, and domestic and family violence—demonstrates that siloed responses are ineffective. Regional settlement planning cannot succeed without a gender lens and integrated approaches that ensure migrant women and their families can thrive safely and equally within regional communities.