This study explores numerical and experimental tools to analyse the impact of the vibration response of Aluminium structural plates in isotropic and at-attachment of anisotropic material. The investigation focuses on the influence of different plate boundary conditions and the effectiveness of PVDF (Poly-vinylidene Fluoride) patches in mitigating vibrations. The PVDF piezo sensor is employed to apply a counteracting force using a 12 V electric input to reduce vibrations. This process is facilitated through a function generator, ME Scope and Samurai software. The study highlights the application of active vibration control in real time to maintain the mission requirements in various fields, such as cargo ships, submarines, marine vehicles, construction, Helicopter blades, aircraft structures and automobiles, where it provides dynamic response to vibration disturbances through its piezoelectric nature. The numerical results obtained using Ansys APDL 2024 R1 show a high degree of agreement with the experimental modal analysis. Validating the accuracy and reliability of the numerical models and the effectiveness of the vibration control strategies employed.