Preserving motion picture films is essential for safeguarding cinematographic heritage and ensuring accessibility for future generations. Film preservation involves several activities to prevent degradation. However, materials like cellulose triacetate (CTA) face significant risks when temperature is higher than 15 °C and relative humidity is higher than 50%. This requires controlled storage conditions. This study examines the environmental and logistical challenges of archival storage, coupling archive energy demand (ED) and climate-induced chemical risks. First, ED was computed for archival storage facilities located in two different climate zones with an emphasis on cooling demand. A degradation model was then applied to analyze the effects of microclimate on CTA, focusing on the chemical decay called ‘Vinegar Syndrome’. Finally, several logistical solutions were simulated to inform how to mitigate cross-contamination and transportation-related risks. The analysis indicates that films stored archives located in Rome (Italy) can reach critical acetic acid levels decades earlier than those in Trondheim (Norway), accelerating Vinegar Syndrome. By addressing the interplay between ED, material degradation, and logistical considerations, this work contributes to the development of cost effective, energy-efficient solutions that align with global sustainability goals.