This chapter is structured to provide a comprehensive exploration of the intricate relationships between chronic pain (CP), opioid use disorders (OUD), and mental health, with a particular focus on the role of dietary strategies as part of an integrative care model. By combining insights from clinical research, epidemiology, and nutritional science, the chapter aims to elucidate how diet can complement conventional therapies to improve outcomes for individuals facing these interconnected challenges. The overarching goal is to provide actionable dietary interventions that can enhance treatment efficacy, support conventional therapies by addressing nutritional deficits and reducing opioid reliance, and promote holistic care. Ultimately, this chapter seeks to offer evidence-based insights and practical recommendations for integrating dietary approaches into the broader framework of care for patients contending with the complex challenges of CP, OUD, and mental health disorders.