Spinal intervention refers to various procedures performed on spinal lesions through a percutaneous approach under the guidance of imaging equipment such as fluoroscopy and angiography, CT, etc. Its application areas are expanding. Fluoroscopy is most widely used in spinal intervention because it provides real-time imaging, clear bone contours, and allows procedures to be performed under guidance from various angles and directions. This chapter introduces epidural steroid injection, facet joint injection/sacroiliac joint injection, vertebroplasty, discography, and spinal biopsy, which are commonly performed in spinal intervention.