Aim: This case series seeks to summarise our experience in diagnosis and management of septic arthritis following anterior cruciate ligament (ACL) surgery. Infection following arthroscopic ACL reconstruction (AACLR) is an uncommon although potentially severe complication. Settings and Design: Case series, prospective study. Materials and Methods: We report four cases of septic arthritis following AACLR. Following initial assessment and intravenous antibiotic administration, the patients had early arthroscopic lavage, debridement, graft retention, and a 6-week course of antibiotics. The postoperative rehabilitation program was followed, and the patients were monitored for a duration of 2 years. The functional evaluation revealed that the patients achieved good to satisfactory outcomes, with no reports of instability. Statistical Analysis Used: Functional outcome measured with Tegner and Lyshlom scores, IKDC, KOOS score, and X-ray. Results: At 2-year follow-up, patients had good functional outcome measured with Tegner and Lyshlom scores, KOOS, IKDC scores, and with no evidence of instability. Conclusion: Infection following arthroscopic anterior cruciate ligament repair (AACLR) is an uncommon yet potentially severe consequence; hence, early diagnosis and appropriate treatment are essential. Diagnosis depends on clinical assessment, laboratory examinations, synovial fluid analysis, and bacterial culture. Our proposed treatment regimen involves performing arthroscopic debridement and irrigation at the earliest opportunity while preserving the graft.