The present work investigates the low-velocity impact (LVI) response of a glass laminate aluminium reinforced epoxy (GLARE) plate having symmetrically placed open holes of different shapes and subjected to a central cylindrical impact. A 3D finite element (FE) code is developed using eight noded layered solid elements considering Hertzian contact law and dynamic analysis under LVI is performed using Newmark-β integration scheme for a clamped square GLARE 5–2/1 plate. The effect of important geometric parameters like the size and shape of the open holes, their relative positions and dimension of the cylindrical impactor on the dynamic response and the associated delamination at the fiber/metal and composite interfaces is assessed and compared to that of a GLARE plate without any holes. Results show that along with the impactor size, the positions as well as size of the holes affect the delamination at the interfaces. It is observed that the free edges around the hole periphery are the critical sites for delamination initiation and the fiber/metal interfaces are most prone to delamination.