In the information era, the information construction in the medical and health industry has become a crucial national development strategy. As the core of medical and health informatization, the construction of information systems has a profound impact on improving the quality and efficiency of medical services, optimizing the allocation and utilization of medical resources, promoting the management and supervision of the medical and health, and enhancing the intelligent governance capabilities of public health. With the continuous progress and application of information technology, the construction of medical and health informatization in China has made great progress, but it is still necessary to continuously strengthen the construction and application of information systems, and improve the integration and innovative capabilities of information technology with the medical and health industry to promote sustainable and healthy development of medical and health undertakings. This chapter will discuss the importance of the medical and health information system, the development status of medical and health informatization in China, and the medical and health information management system in China, to provide insights into the current status, issues, and future directions of medical and health informatization in China.