This study examines the impact of digital entrepreneurship on the financial performance of women-led MSMEs in Indonesia, focusing on the moderating roles of gender and innovation adoption. Using a mixed-methods approach, we combined stakeholder interviews and surveys from 178 Java-based MSMEs, which analyzed the results through OLS regression, robustness tests, and classical assumption checks with R-Studio software. Grounded in the Resource-Based View, Diffusion of Innovations, and Gender & Entrepreneurship theories, our findings reveal three key insights: (1) While digital tools initially increase operational costs, they ultimately enhance profitability through improved cost efficiency and sales growth, particularly in food/beverage and creative sectors; (2) Gender significantly moderates this relationship. Women-led MSMEs demonstrate superior sales conversion rates despite lower technology investments, highlighting their relational business approaches and adaptive strategies; and (3) Innovation adoption especially e-commerce integration and digital sales ratios, as key amplifiers of financial performance. The research advances theoretical understanding by demonstrating gender-differentiated resource utilization patterns and contextual innovation adoption barriers in emerging economies. Limitations include the Java-centric sample, suggesting the need for broader geographical studies. These insights support economic inclusivity toward the vision of a Golden Indonesia 2045, especially for women-led entrepreneurs.